Publications

(*Co-correspondence, +equally contributed)

2026
60

New biotemplating study

Nakhyun Kim et al.  ·  Under review

59

New neuromorphic device

Chan Kang et al.  ·  Under review

58

New material synthesis technique

Changwoo Song et al.  ·  In revision

57

All-trans retinoic acid suppresses CD8+ T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma

In Kang, Yumin Kim, Byeong Hoon Kang, Hyun-Jin Kim, Eunwoo Kim, Chae Won Kim, Hyeon Cheol Kim, Sang Hee Park, Won Hyung Park, Seo Hyeon Im, Na Eun Kim, Sungwoo Chang, Jeongwoo La, Inju Hwang, Minji Kim, Stephen Ahn, Sung Ki Lee, Jae-Byum Chang, Heung Kyu Lee

Signal Transduction and Targeted Therapy (2026)
56

Graph-based modeling of optical system enables adaptive optics on dynamic samples with self-calibration

E.-S. Cho+, J. Park+, H. Jin, Y. Chung, M. Eom, H. Shin, J.-B. Chang, J.-H. Park*, Y.-G. Yoon*

iScience (2026) →
55

A disulfide–Fe3+ crosslinking strategy for tough hydrogel networks with complete photo- and biochemical degradability

Young Bin Yoon, Nakhyun Kim, Hoeyun Jung, Yoonha Ko, Chan Kang, Jooyeun Chong, Jiheong Kang, Dongmin Kang, Jae-Byum Chang*

Materials Horizons (2026) →
54

Abunmix enables the simple and robust multiplexed immunofluorescence imaging

Woonggi La+, Seoungbin Bae+, Junyoung Seo+, Hayeong Yu+, Junmo Cho, Hyunwoo Kim, Hoyeon Nam, Seungjae Han, Euiin Yi, Eunsu Kim, Chan Kang, Hyejin Shin, Chang Woo Song, Young-Gyu Yoon*, Jae-Byum Chang*

VIEW (2026) →
53

Nanobody-Based Biotemplating Enables Nanoscale-Precision Metallization of Cellular, Tissue, and Plant Architectures

Hoeyun Jung‡, Dae-Hyeon Song‡, Seonghun Kim, Tae-Kyeong Jeong, Yongsuk Hur, Dongmin Kang, Ji-Joon Song, Giltsu Choi, Jae-Byum Chang*

ACS Applied Materials & Interfaces (2026) →
2025
52

Highly accurate image registration for 3D multiplexed cyclic imaging using dense labeling in expandable tissue gels

Hyunwoo Kim, Joon-Goon Kim, Jueun Sim, Hoyeon Nam, In Cho, Hyejin Shin, Junyoung Kwon, Dae-Hyeon Song, Seoungbin Bae, Young-Gyu Yoon*, Taeyun Ku*, Jae-Byum Chang*

PLOS Biology 23, e3003240 (2025) →
51

MAX Eraser: An affordable and simple reagent for antibody removal cycle in multiplex immunohistochemistry

Si-Hyung Park, Boram Lee, Injae Kim, Junyoung Seo, Jeongah Kim, Jae Ryun Ryu, Jae-Byum Chang, Hyunwoo J. Kim, Woong Sun*

Cell Biomaterials 1, 100096 (2025) →
50

Doubling multiplexed imaging capability via spatial expression pattern-guided protein pairing and computational unmixing

Gyuri Kim, Hyejin Shin, Minho Eom, Hyunwoo Kim, Jae-Byum Chang*, Young-Gyu Yoon*

Communications Biology 8, 928 (2025) →
49

Reciprocal folding dynamics in cellular networks at the stroma-basement membrane interface

Youngmin Jo, Donghyun Yim, Chan E Park, Insung Yong, Jongbeom Lee, Kwang Ho Ahn, Chanhee Yang, Jae-Byum Chang, Taek-Soo Kim, Jennifer Hyunjong Shin, Taeyoon Kim, Pilnam Kim*

Acta Biomaterialia 201, 360–371 (2025) →
48

Metal-phenolic networks reverse the immunosuppressive tumor microenvironment via dual metabolism regulation and immunogenic cell death

Hoyeon Nam, Heewon Park, Mi Kwon Son, In Kang, Yuri Choi, Susam Lee, Sejin Kim, Seungcheol Kim, Hyunwoo Kim, Jae-Byum Chang, Yong-kyu Lee, Yeu-Chun Kim*

Journal of Controlled Release 383, 113775 (2025) →
47

Nanoscale Resolution Imaging of Whole Mouse Embryos Using Expansion Microscopy

Jueun Sim+, Chan E Park+, In Cho+, Kyeongbae Min, Minho Eom, Seungjae Han, Hyungju Jeon, Eun-Seo Cho, Yunjeong Lee, Young Hyun Yun, et al., Young-Gyu Yoon*, and Jae-Byum Chang*

ACS Nano 19(8), 7910–7927 (2025) →
46

Elasticity of Swollen and Folded Polyacrylamide Hydrogel Using the MARTINI Coarse-Grained Model

Seunghyok Rho, Heeyuen Koh, Ji Woong Yu, Hye Been Koo, Sebin Kim, Je-Yeon Jung, EunYeong Jung, Chongyong Nam, Jae Young Lee, Kyounghwa Jeon, Jae-Byum Chang*, Do-Nyun Kim*, Won Bo Lee*

ACS Applied Materials & Interfaces 17(3), 5340–5351 (2025) →
2024
45

Rewritable Wavelength-Selective Hydrogel Actuators Grafted with Fluorophores

Hye Been Koo, Haemin Yeon, Young Bin Yoon, Taek-Jun Lee, Young-Tae Chang, Jae-Byum Chang*

Materials Horizons 12(7), 2255–2266 (2025) →
44

Selectively Detachable Hydrogel Adhesion Enabled by Stimulus-Specific Cleavable Cross-Linkers

Yoon, Young Bin; Cho, In; Koo, Hye Been; Jung, Hoeyun; Chang, Jae-Byum*

ACS Applied Materials & Interfaces 16(48), 66738–66752 (2024) →
43

Hydrogel-based 3D fabrication of multiple replicas with varying sizes and materials from a single template via iterative shrinking

E. Heo, J. Yang, I. Cho, H. Lee, S. Park, and J. Chang*

Soft Matter 20(46), 9249–9260 (2024) →
42

Highly Tunable, Nanomaterial-Functionalized Structural Templating of Intracellular Protein Structures Within Biological Species

Dae-Hyeon Song+, Chang Woo Song+, Seunghee H. Cho+, Tae Yoon Kwon, Hoeyun Jung, Ki Hyun Park, Jiyun Kim, Junyoung Seo, Jaeyoung Yoo, Minjoon Kim, Gyu Rac Lee, Hyuck Mo Lee, Jennifer H. Shin, Yeon Sik Jung*, Jae-Byum Chang*

Advanced Science 12(2), 2406492 (2025) →
41

Control of the signaling role of PtdIns(4)P at the plasma membrane through H2O2-dependent inactivation of synaptojanin 2 during endocytosis

S. Jo, S. Kim, J. M. Lim, S. G. Rhee, B. Jeong, S. Cha, J. Chang, and D. Kang*

Redox Biology 71, 103097 (2024) →
2023
40

Precise and Selective Macroscopic Assembly of Dual Lock-and-Key Structured Hydrogel

E. Heo, W. Hwang, H. Koo, S. Park, D. Kim, H. Kim, Y. Kim, and J. Chang*

Materials Horizons 11(2), 428–441 (2024) →
39

Metallization of targeted protein assemblies in cell-derived extracellular matrix by antibody-guided biotemplating

C. Song+, J. Ahn+, I. Yong, N. Kim, C. Park, S. Kim, S. Chung, P. Kim, I. Kim*, J. Chang*

Cover article Advanced Science 10(35), 2302830 (2023) →
38

Statistically unbiased prediction enables accurate denoising of voltage imaging data

M. Eom, S. Han, P. Park, G. Kim, E. Cho, J. Sim, K. Lee, S. Kim, H. Tian, U. Bohm, et al., and Y. Yoon*

Nature Methods 20(10), 1581–1592 (2023) →
37

Expandable ELAST for super-resolution imaging of thick tissue slices using a hydrogel containing charged monomers

W. La, J. Seo, E. Heo, and J. Chang*

Scientific Reports 13, 11929 (2023) →
36

Human hand-inspired all-hydrogel gripper with high load capacity formed by the split-brushing adhesion of diverse hydrogels

H. Koo, E. Heo, I. Cho, S. Kim, J. Kang, and J. Chang*

Materials Horizons 10(6), 2075–2085 (2023) →
35

Glycation-mediated tissue-level remodeling of brain meningeal membrane by aging

H. M. Kim, S. Kim, J. Sim, B. S. Ma, I. Yong, Y. Jo, T.-S. Kim, J. Chang, S.-H. Park, Y. Jeong* and P. Kim*

Aging Cell 22(5), e13805 (2023) →
2022
34

In-situ silver nanoparticle development for molecular-specific biological imaging via highly accessible microscopies

D. Song, C. W. Song, J. Chung, E. Jang, H. Kim, Y. Hur, E. Hur, D. Kim*, and J. Chang*

Nanoscale Advances 5(6), 1636–1650 (2023) →
33

Strong, Chemically Stable, and Enzymatically On-Demand Detachable Hydrogel Adhesion Using Protein Crosslink

W. Lee, E. Heo, H. Koo, I. Cho, and J. Chang*

Macromolecular Rapid Communications 44(4), 2200750 (2023) →
32

Chitosan-coated Mesoporous Silica Particles as a Plastic-free Platform for Photochemical Suppression and Stabilization of Organic Ultraviolet Filters

S. Choi, H. Na, R. Rahman, J. Sim, J. Chang, and Y. Nam*

Journal of Photochemistry & Photobiology, B 235, 112565 (2022) →
31

Imaging cell biology

B. Andrews, J. Chang, L. Collinson, D. Li, E. Lundberg, J. Mahamid, S. Manley, et al.

Nature Cell Biology 24(8), 1180–1185 (2022) →
30

Multiscale Functional Metal Architectures by Antibody-Guided Metallization of Specific Protein Assemblies in Ex Vivo Multicellular Organisms

C. Song+, D. Song+, D. Kang, K. Park, C. Park, H. Kim, Y. Hur, S. Jo, Y. Nam, J. Yeom, S. Han, and J. Chang*

Frontispiece featured Advanced Materials 34(35), 2200408 (2022) →
29

PICASSO allows ultra-multiplexed fluorescence imaging of spatially overlapping proteins without reference spectra measurements

J. Seo+, Y. Sim+, J. Kim+, H. Kim, I. Cho, H. Nam, Y. Yoon*, J. Chang*

Nature Communications 13, 2475 (2022) →
28

Fabrication of Heterogeneous Chemical Patterns on Stretchable Hydrogels Using Single-Photon Lithography

H. Im, E. Heo, D. Song, J. Park, H. Park, K. Kang, and J. Chang*

Soft Matter 18(23), 4402–4413 (2022) →
27

Simultaneous amplification of multiple immunofluorescence signals via cyclic staining of target molecules using mutually cross-adsorbed antibodies

H. Yeon, Y. Cho, J. Seo, Y. Sim, J. Chang*

Scientific Reports 12, 8780 (2022) →
26

Simultaneous expansion microscopy imaging of proteins and mRNAs via dual-ExM

I. Cho and J. Chang*

Top 100 in Cell and Molecular Biology – 2022 Scientific Reports 12, 3360 (2022) →
2021 and earlier
25

Artificial Taste Buds: Bioorthogonally Ligated Gustatory–Neuronal Multicellular Hybrids Enabling Intercellular Taste Signal Transmission

L. Trang Huyen, B. Koo, S. Jo, N. Liang, M. Yang, I. Cho, J. Chang, T. Wang, Y. Nam*

ACS Biomater. Sci. Eng. 7(8), 3783–3792 (2021) →
24

FRACTAL: Signal amplification of immunofluorescence via cyclic staining of target molecules

Y. Cho, J. Seo, Y. Sim, J. Chung, C. Park, C. Park, D. Kim, and J. Chang*

Nanoscale 12(46), 23506–23513 (2020) →
23

Super-Resolution Three-Dimensional Imaging of Actin Filaments in Cultured Cells and the Brain via Expansion Microscopy

C. Park, Y. Cho, I Cho, H. Jung, B. Kim, J. Shin, S. Choi, S. Kwon, Y. Han, and J. Chang*

ACS Nano 14(11), 14999–15010 (2020) →
22

Multiplexed expansion microscopy of the brain through fluorophore screening

K. Min, I. Cho, M. Choi, and J. Chang*

Methods 174, 3–10 (2020) →
21

Directed self-assembly of a two-state block copolymer system

H. W. Do, H. K. Choi, K. R. Gadelrab, J. Chang, A. Alexander-Katz, C. A. Ross, and K. K. Berggren

Nano Convergence 5, 25 (2018) →
20

Expansion microscopy

I. Cho, J. Seo, and J. Chang*

Journal of Microscopy 271(2), 123–128 (2018) →
19

Feasibility of 3D Reconstruction of Neural Morphology Using Expansion Microscopy and Barcode-Guided Agglomeration

Y. Yoon, P. Dai, J. Wohlwend, J. Chang, A. H. Marblestone, E. S. Boyden

Frontiers in Computational Neuroscience 11, 97 (2017) →
18

Iterative expansion microscopy

J. Chang, F. Chen, Y. Yoon, E. E. Jung, H. Babcock, J. S. Kang, S. Asano, H. Suk, N. Pak, P. W. Tillberg, A. Wassie, D. Cai, E. S. Boyden

Key publication Nature Methods 14(6), 593–599 (2017) →
17

Nanoscale Spirals by Directed Self-Assembly

H. K. Choi*, J. Chang*, A. Hannon, J. Yang, A. Alexander-Katz, K. K. Berggren, and C. A. Ross (*equal contribution)

Nano Futures 1(1), 015001 (2017) →
16

Nanoscale imaging of RNA with expansion microscopy

F. Chen, A. T. Wassie, A. J. Cote, A. Sinha, S. Alon, S. Asano, E. R. Daugharthy, J. Chang, A. Marblestone, G. M. Church, A. Raj, E. Boyden

Nature Methods 13(8), 679–684 (2016) →
15

Hybrid Microscopy: Enabling Inexpensive High-Performance Imaging through Combined Physical and Optical Magnifications

Y. S. Zhang*, J. Chang*, M. Alvarez, G. Trujillo-deSantiago, J. Aleman, B. Batzaya, et al., E. Boyden, and A. Khademhosseini (*equal contribution)

Scientific Reports 6, 22691 (2016) →
14

The orientations of large aspect-ratio coiled-coil proteins attached to gold nanostructures

J. Chang*, Y. H. Kim*, E. Thompson, Y. H. No, N. H. Kim, J. Arrieta, V. R. Manfrinato, A. Keating, and K. K. Berggren (*equal contribution)

Small 12(11), 1498–1505 (2016) →
13

Two-dimensional nanoparticle supracrystals: a model system for two-dimensional melting

J. Y. Kim, S. J. Kwon, J. Chang, C. A. Ross, A. T. Hatton, and F. Stellacci

Nano Letters 16(2), 1352–1358 (2016) →
12

Three-dimensional nanofabrication using HSQ/PMMA bilayer resists

H. W. Do, J. Chang, and Karl K. Berggren

J. Vac. Sci. Technol. B 32(6), 06F501 (2014) →
11

Three-dimensional nanofabrication in block copolymer self-assembly

C. A. Ross, Karl K. Berggren, Joy Y. Cheng, Yeon Sik Jung, and J. Chang

Advanced Materials 26(25), 4386–4396 (2014) →
10

Design rules for self-assembled block-copolymer patterns using tiled-templates

J. Chang, H. K. Choi, A. F. Hannon, A. Alexander-Katz, C. A. Ross, and K. K. Berggren

Nature Communications 5, 3305 (2014) →
9

Seeded solution growth of nanoparticles into ordered three-dimensional supracrystals

J. Y. Kim, J. Chang, C. A. Ross, and F. Stellacci

RSC Advances 3(27), 10628 (2013) →
8

Bubble nucleation on nano- to micro-size cavities and posts: an experimental validation of classical theory

S. Witharana, B. Philips, S. Strobel, H. D. Kim, J. Chang, et al.

Journal of Applied Physics 112(6), 064904 (2012) →
7

Aligned sub-10-nm block copolymer patterns templated by post arrays

J. Chang, J. G. Son, Adam F. Hannon, et al.

ACS Nano 6(3), 2071–2077 (2012) →
6

Assembly of sub-10-nm block copolymer patterns with mixed morphology and period using electron irradiation and solvent annealing

J. G. Son, J. Chang, K. K. Berggren, and C. A. Ross

Nano Letters 11(11), 5079–5084 (2011) →
5

Highly ordered square arrays from a templated ABC triblock terpolymer

J. G. Son, J. Gwyther, J. Chang, K. K. Berggren, I. Manners, and C. A. Ross

Nano Letters 11(7), 2849–2855 (2011) →
4

Sub-10-nm structures on silicon by thermal dewetting of platinum

S. Strobel, C. Kirkendall, J. Chang, K. K. Berggren

Nanotechnology 21(50), 505301 (2010) →
3

Complex self-assembled patterns using sparse commensurate templates with locally varying motifs

J. K. W. Yang, Y. S. Jung, J. Chang, et al.

Nature Nanotechnology 5(4), 256–260 (2010) →
2

A path to ultra-narrow patterns using self-assembled lithography

Y. S. Jung, J. Chang, E. Verploegen, Karl K. Berggren, and C. A. Ross

Nano Letters 10(3), 1000–1005 (2010) →
1

Templated self-assembly of Si-containing block copolymers for nanoscale device fabrication

C. A. Ross, Y.S. Jung, V. P. Chuang, J. G. Son, K. W. Gowtrik, R. A. Mickiewicz, J. K. W. Yang, J. Chang, et al.

Proc. SPIE 7637, 76370H (2010) →
Book Chapters
3

Light-Sheet Fluorescence Microscopy for Multiscale Biological Imaging

J. Chang, R. Gao, and F. Chen

Book chapter Molecular Imaging (2021) →
2

Expansion microscopy imaging of various neuronal structures

I. Cho, J. Sim, J. Chang

Book chapter Methods in Cell Biology vol.161 (2021) →
1

Expansion Microscopy for Brain Imaging

J. Chang

Book chapter Advanced Optical Methods for Brain Imaging (2019) →