We treat tissue imaging as a precision engineering system — integrating novel chemistry, automated processes, AI-based analysis, and nanofabrication to produce large-scale, quantitative spatial biology data. Our goal is to map the molecular architecture of cancer and the brain at nanoscale resolution, and to translate these biological blueprints into next-generation semiconductor devices.
End-to-end optimization of the full imaging workflow — from tissue preparation and labeling chemistry to microscopy, image registration, and quantitative analysis — to generate accurate, reproducible, high-dimensional spatial datasets from cancer and brain tissues.
Engineering neuronal architectures through surface patterning and molecular control, then linking structural imaging readouts to metallization, electrical characterization, and device behavior — toward new bioelectronic and neuromorphic platforms.
Chemical and materials strategies that enhance imaging capability — including expansion microscopy, hydrogel engineering, and labeling chemistry — to improve structural fidelity, signal accessibility, and multiplexing performance across diverse tissues.
Jueun Sim+, Chan E Park+, In Cho+, et al. · ACS Nano 19(8), 7910–7927 (2025)
ACS Nano 19(8), 7910–7927 (2025) →Dae-Hyeon Song+, Chang Woo Song+, Seunghee H. Cho+, et al. · Advanced Science 12(2), 2406492 (2025)
Advanced Science 12(2), 2406492 (2025) →C. Song+, D. Song+, D. Kang, et al. · Advanced Materials 34(35), 2200408 (2022)
Frontispiece featured Advanced Materials 34(35), 2200408 (2022) →J. Seo+, Y. Sim+, J. Kim+, et al. · Nature Communications 13, 2475 (2022)
Nature Communications 13, 2475 (2022) →J. Chang, F. Chen, Y. Yoon, et al. · Nature Methods 14(6), 593–599 (2017)
Key publication Nature Methods 14(6), 593–599 (2017) →Principal Investigator
PhD Student
PhD Student
PhD Student
PhD Student
PhD Student
PhD Student
PhD Student
MS Student
MS Student
We are actively recruiting motivated MS/PhD students with backgrounds in biology, chemistry, physics, or engineering. Positions are available each semester.
Inquire →Candidates with expertise in imaging, soft matter, or single-cell biology are encouraged to reach out with a CV and brief statement of research interests.
Inquire →Motivated undergraduates can join through UROP or informal internship programs. Reach out early in the semester.
Inquire →Department of Materials Science and Engineering
KAIST, Daejeon, South Korea
jbchang [at] kaist.ac.kr